解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
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牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
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传染病
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医学伦理学
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医学实验室技术
医学,全科和内科
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神经系统科学
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营养学和饮食学
产科医学和妇科医学
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药理学和药剂学
生理学
基本医疗保健
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放射学,核医学和医学成像
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热带医学
泌尿学和肾脏学
病毒学
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健康政策和服务
心理学,临床
abstract::The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935639
更新日期:1993-07-01 00:00:00
abstract::Antibodies are increasingly being used as tools to study the function of cell surface markers. Several types of responses may occur upon the selective binding of an antibody to an epitope on a receptor. Antibody binding may trigger signals that are normally transduced by endogenous ligands. Moreover, antibody binding ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02780606
更新日期:1993-04-01 00:00:00
abstract::The question of how the cell surface molecules may be specifically delivered to subdomains of neurons is of particular interest considering that polarized sorting to the axon could enable adhesion glycoproteins to induce fasciculation of axonal tracts, guidance to the target cell, and the establishment of synaptic con...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02780608
更新日期:1993-04-01 00:00:00
abstract::Previous studies have provided evidence for axon-to-myelin transfer of intact lipids and lipid precursors for reutilization by myelin enzymes. Several of the lipid constituents of myelin showed significant contralateral/ipsilateral ratios of incorporated radioactivity, indicative of axonal origin, whereas proteins and...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02780551
更新日期:1992-07-01 00:00:00
abstract::Long-term potentiation (LTP), a long-lasting, activity-dependent increase in the strength of synaptic transmission, is one of the most intensively studied forms of synaptic plasticity in the mammalian brain. In the CA1 region of the hippocampus, the induction of LTP is likely to require a rise in postsynaptic calcium ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935552
更新日期:1991-01-01 00:00:00
abstract::Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elev...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935554
更新日期:1991-01-01 00:00:00
abstract::Many neurotransmitters and hormones activate receptors that are known to be coupled to their effectors by GTP-binding regulatory proteins, G proteins. Activation of many of these same receptors elicits arachidonate release and metabolism. During the past few years, novel experimental techniques have revealed that in m...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935629
更新日期:1989-10-01 00:00:00
abstract::This review describes the modulation of the GABAa receptor by steroid hormones and barbiturates and proposes guidelines for further research. Having examined the complex organization of the GABAa receptor complex and the multiple allosteric interactions between its drug and transmitter/modulator binding sites, the pos...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02740608
更新日期:1989-01-01 00:00:00
abstract::The study of neurite growth in tissue culture has been a productive way to identify substances that may control the behavior of axons in vivo. Molecules that promote the outgrowth of neurites include nerve growth factor, laminin, fibronectin, and a protease inhibitor derived from glia. Evidence that these molecules ma...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02936609
更新日期:1987-10-01 00:00:00